Search results for " Ovarian senescence"

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Ovarian senescence increases liver fibrosis in humans and zebrafish with steatosis

2015

ABSTRACT Contrasting data exist on the effect of gender and menopause on the susceptibility, development and liver damage progression in non-alcoholic fatty liver disease (NAFLD). Our aim was to assess whether menopause is associated with the severity of liver fibrosis in individuals with NAFLD and to explore the issue of ovarian senescence in experimental liver steatosis in zebrafish. In 244 females and age-matched males with biopsy-proven NAFLD, we assessed anthropometric, biochemical and metabolic features, including menopausal status (self-reported); liver biopsy was scored according to ‘The Pathology Committee of the NASH Clinical Research Network’. Young and old male and female zebraf…

Liver CirrhosisMaleFibrosiBiopsyPhysiologylcsh:MedicineMedicine (miscellaneous)Body Mass IndexCohort StudiesImmunology and Microbiology (miscellaneous)FibrosisNon-alcoholic Fatty Liver DiseaseRisk FactorsOdds RatioZebrafishCellular Senescencemedicine.diagnostic_testAnthropometryFatty liverMiddle AgedOvarian senescenceMenopauseLiver biopsyModels AnimalDisease ProgressionFemaleMenopauselcsh:RB1-214Research ArticleSenescenceAdultmedicine.medical_specialtyFibrosis Menopause Non-alcoholic fatty liver disease Ovarian senescence ZebrafishNeuroscience (miscellaneous)Fibrosis; Menopause; Non-alcoholic fatty liver disease; Ovarian senescence; Zebrafish; Biochemistry Genetics and Molecular Biology (all); Medicine (miscellaneous); Immunology and Microbiology (miscellaneous); Neuroscience (miscellaneous)BiologyReal-Time Polymerase Chain ReactionGeneral Biochemistry Genetics and Molecular BiologyInternal medicinemedicinelcsh:PathologyAnimalsHumansAgedBiochemistry Genetics and Molecular Biology (all)lcsh:RSettore MED/09 - MEDICINA INTERNAOvaryOdds ratiomedicine.diseaseFibrosisEndocrinologySteatosisBody mass indexDisease Models & Mechanisms
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